abstract：:BACKGROUND In this study we investigated changes in the status of antibiotic use in Tianjin since the implementation of the Antibiotic Stewardship Program (ASP) (2011-2013), as well as existing problems, strategies, and outcomes to promote rational clinical antibiotic use. MATERIAL AND METHODS A quasi-experimental stu...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang HH,Du Y,Liu W,Song SD,Zhao W,Huang GW,Wang HS

更新日期：2017-02-09 00:00:00

abstract：:BACKGROUND Platinum-based chemotherapy is the most effective regimen for nasopharyngeal carcinoma, which presents highly invasive and metastatic activity. However, the dose-related toxicity of chemotherapy agents limits the dose administration. Astragalus polysaccharide (APS) is the major active ingredient extracted f...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhou Z,Meng M,Ni H

更新日期：2017-01-26 00:00:00

abstract：:BACKGROUND Nimotuzumab is an anti-EGFR monoclonal antibody which has been widely used in cancer treatment. However, the safety and efficacy of nimotuzumab combined with chemotherapy in locally advanced or metastatic esophageal cancer patients remain unclear. MATERIAL AND METHODS To address this open question, we colle...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Han X,Lu N,Pan Y,Xu J

更新日期：2017-01-24 00:00:00

abstract：:BACKGROUND Leptin plays a crucial role in bone metabolism, and its level is related to bone callus formation in the fracture repair process. The objective of this study was to evaluate the effect of recombinant leptin on the healing process of femoral fractures in rats. MATERIAL AND METHODS Forty-eight male Sprague Da...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu P,Cai M

更新日期：2017-01-15 00:00:00

abstract：:BACKGROUND The aim of this study was to detect the expression of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) and estimate its diagnostic value in prostate cancer (PCa). MATERIAL AND METHODS EFEMP1 expression in serum and urine of patients with PCa, benign controls and health...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Shen H,Zhang L,Zhou J,Chen Z,Yang G,Liao Y,Zhu M

更新日期：2017-01-13 00:00:00

abstract：:Telomeres are located at each end of eukaryotic chromosomes. Their functional role is genomic stability maintenance. The protective role of telomeres depends on various factors, including number of nucleotides repeats, telomere-binding proteins, and telomerase activity. Organ transplantation is the preferred replaceme...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Kłoda K,Domański L,Mierzecki A

更新日期：2017-01-11 00:00:00

abstract：:BACKGROUND Polycystic ovary syndrome (PCOS) is a complex disease that has both genetic and environmental components. Adiponectin plays an important role in the regulation of insulin sensitivity and insulin resistance (IR) in PCOS. The aim of this study was to determine 2 single-nucleotide polymorphisms (SNPs) variants...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Sun X,Wu X,Duan Y,Liu G,Yu X,Zhang W

更新日期：2017-01-06 00:00:00

abstract：:BACKGROUND We scrutinized the feasibility of apoptosis induction in blood cancer cells by means of low-intensity ultrasound and the proteasome inhibitor bortezomib (Velcade). MATERIAL AND METHODS Human leukemic monocyte lymphoma U937 cells were subjected to ultrasound in the presence of bortezomib and the echo contras...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Saliev T,Feril LB Jr,Ogawa K,Watanabe A,Begimbetova D,Molkenov A,Alimbetov D,Tachibana K

更新日期：2016-12-22 00:00:00

abstract：:BACKGROUND Stroke is a serious health problem all over the world. Ischemia causes 85% of strokes and 75% of these ischemic strokes occur within the area supplied by the internal carotid artery (ICA). MATERIAL AND METHODS This study included 47 acute stroke patients who were in the large-artery atherosclerosis group ac...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Alagoz AN,Acar BA,Acar T,Karacan A,Demiryürek BE

更新日期：2016-12-16 00:00:00

abstract：:BACKGROUND The aim of this study was to explore the regulating effects of Substance P (SP) on the collagen synthesis of rat myocardial fibroblasts (CFBs) induced by angiotensin II (Ang II) and its potential mechanism. MATERIAL AND METHODS The CFBs of a neonatal SD rat were separately cultured and divided into the cont...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yang Z,Zhang X,Guo N,Li B,Zhao S

更新日期：2016-12-16 00:00:00

abstract：:BACKGROUND Heterozygous beta thalassemia (HBT) has been proposed to increase the risk of developing autoimmune disease. Our aim in this study was to examine the prevalence of HBT among multiple sclerosis (MS) patients. MATERIAL AND METHODS HBT frequency was investigated in our MS group (243 patients with MS). Hemoglob...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Cikrikcioglu MA,Ozcan ME,Halac G,Gultepe I,Celik K,Sekin Y,Eser EE,Burhan S,Cetin G,Uysal O

更新日期：2016-12-11 00:00:00

abstract：:BACKGROUND Lower limb and pelvic injuries and fractures occur at a very high incidence in motor vehicle accidents. In this study, the characteristics (e.g., body side, bone location, and fracture severity) of lower limb and pelvic fractures that occurred during front-impact collisions were correlated with the injured ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Gokalp MA,Hekimoglu Y,Gozen A,Guner S,Asirdizer M

更新日期：2016-12-01 00:00:00

abstract：:BACKGROUND This study aimed to establish an easy, safe, and cost-saving intestinal anastomotic method. MATERIAL AND METHODS Between January 2014 and February 2016, a total of 150 patients with gastric cancer who underwent surgery in the Department of General Surgery of Xuzhou Medical University Affiliated Hospital wer...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yao L,Li C,Zhu X,Shao Y,Meng S,Shi L,Wang H

更新日期：2016-11-26 00:00:00

abstract：:BACKGROUND Osteoarthritis (OA) progressively produces symptoms and disability that may significantly reduce health-related quality of life (HRQoL). Total hip arthroplasty (THA) is an important treatment for symptomatic OA. An alternative to standard-stem THA for younger patients is short-stem THA. The aim of this stud...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Henry BM,Wrażeń W,Hynnekleiv L,Kłosiński M,Pękała PA,Kucharska E,Golec EB,Tomaszewski KA,Pąchalska M

更新日期：2016-11-17 00:00:00

abstract：:BACKGROUND Oxidative DNA damage is associated with male infertility. The aim of this study was to evaluate the oxidative DNA damage of sperm cells and blood leukocytes and to determine the levels of MDA and NO levels in seminal and blood plasma of idiopathic infertile men. MATERIAL AND METHODS The study enrolled 52 pa...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Taken K,Alp HH,Eryilmaz R,Donmez MI,Demir M,Gunes M,Aslan R,Sekeroglu MR

更新日期：2016-11-11 00:00:00

abstract：:BACKGROUND The aim of this study was to investigate relationships between early atherosclerosis and inflammatory bowel disease (IBD) using laboratory, functional, and morphological markers of atherosclerosis. MATERIAL AND METHODS In the present prospective single-center study, 96 patients with IBD (58 patients with ul...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Üstün Y,Kilincalp S,Çoban Ş,Coşkun Y,Yüksel İ,Ongun A,Soykan İ,Bektaş M,Törüner M,Çetinkaya H,Örmeci N

更新日期：2016-10-24 00:00:00

abstract：:BACKGROUND Although tendinopathy is common, its underlying pathogenesis is poorly understood. This study aimed to investigate the possible pathogenesis of tendinopathy. MATERIAL AND METHODS In this study, a total of 24 rats were randomly and evenly divided into a control (CON) group and a strenuous treadmill running (...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xu SY,Li SF,Ni GX

更新日期：2016-10-15 00:00:00

abstract：:BACKGROUND Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non-melanoma skin cancer (NMSC) globally. The aims of this study were to further systematically clarify the potential association of rs833061 (-460 C>T) and rs1570360 (-1154 G>A), two SNPs of VEGF, with the risk of cSCC and the progn...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Nie XJ,Liu WM,Zhang L

更新日期：2016-10-12 00:00:00

abstract：:BACKGROUND The STin2 VNTR polymorphism has a variable number of tandem repeats in intron 2 of the serotonin transporter gene. We aimed to explore the relationship between STin2 VNTR polymorphism and lifelong premature ejaculation (LPE). MATERIAL AND METHODS We recruited a total of 115 outpatients who complained of eja...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Huang Y,Zhang X,Gao J,Tang D,Gao P,Peng D,Liang C

更新日期：2016-10-07 00:00:00

abstract：:BACKGROUND Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. Our previous study showed that GOLPH3 expression in glioma tissues was related to the severity of the malignancy of the cancer. However, the mechanism by which GOLPH3 affects cell apoptosis is large...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li X,Li M,Tian X,Li Q,Lu Q,Jia Q,Zhang L,Yan J,Li X,Li X

更新日期：2016-10-04 00:00:00

abstract：:BACKGROUND Septin9 is a member of GTP-binding protein family, and is used as a predictive diagnostic index. However, it has not been widely adopted due to inconsistent results reported in the literature. The present study was performed to determine the diagnostic accuracy of methylated Septin9 (mSEPT9) for colorectal ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yan S,Liu Z,Yu S,Bao Y

更新日期：2016-09-25 00:00:00

abstract：:BACKGROUND Calcium overload, inflammation, and apoptosis play important roles in myocardial ischemia-reperfusion injury (MIRI). Gastrodin pretreatment can alleviate MIRI. This study observed sarcoplasmic reticulum calcium transport ATPase (Ca2+-ATPase, SERCA) and calcium phosphate (PLB) protein expression in the ventr...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li Y,Wang X,Lou C

更新日期：2016-09-19 00:00:00

abstract：:BACKGROUND Fine particulate matter with aerodynamic diameters smaller than 2.5 μm (PM2.5) has been reported to cause adverse effects on human health. Evidence has shown the association between PM2.5 exposure and adverse perinatal outcomes, and the most common method is epidemiological investigation. We wished to inves...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu Y,Wang L,Wang F,Li C

更新日期：2016-09-15 00:00:00

abstract：:Cataract is the leading cause of irreversible blindness worldwide. Increasing evidence indicates that oxidative stress is an important risk factor contributing to the development of cataract. Moreover, the enhancement of the antioxidant defense system may be beneficial to prevent or delay the cataractogenesis. The ter...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Qin L,Tao Y,Wang L,Chen H,Liu Y,Huang YF

更新日期：2016-09-08 00:00:00

abstract：:BACKGROUND The World Health Organization (WHO) histological classification for gastric cancer is widely accepted and used. However, its impact on predicting lymph node metastasis and recurrence in early gastric cancer (EGC) is not well studied. MATERIAL AND METHODS From 1987 to 2005, 2873 EGC patients with known WHO h...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Lai JF,Xu WN,Noh SH,Lu WQ

更新日期：2016-09-05 00:00:00

abstract：:BACKGROUND Transplantation with allogeneic cells has become a promising modality for cancer therapy, which can induce graft-versus-tumor (GVT) effect. This study was aimed at assessing the safety, efficacy, and tissue type GVT (tGVT) response of transplantation with allogeneic skin tumors to treat chemically-induced s...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang Z,Sun H,Zhang J,Ge C,Dong S,Li Z,Li R,Chen X,Li M,Chen Y,Zou Y,Qian Z,Yang L,Yang J,Zhu Z,Liu Z,Song X

更新日期：2016-09-02 00:00:00

abstract：:BACKGROUND The aim of this study was to provide valid data for a plate-screw fixation model for fractured posterior-anterior columns of the acetabulum. MATERIAL AND METHODS Nineteen cadaveric bony hemi-pelvis specimens were obtained and 50 healthy adults were enrolled. The modified Stoppa approach and computed tomogra...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xu Y,Lin C,Zhang L,Lin M,Lai J,Cao S,Peng G,Feng K,Yan G,Cai D,Wang G

更新日期：2016-09-01 00:00:00

abstract：:Osterix (Osx) is an osteoblast-specific transcription factor that is essential for bone formation. MicroRNAs (miRNAs) are ~22-nucleotide-long noncoding RNAs that play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. They can also control osteoblast-mediated ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang C,Liao H,Cao Z

更新日期：2016-08-20 00:00:00

abstract：:BACKGROUND Simazine is a triazine herbicide used worldwide in both agricultural and non-agricultural fields that is frequently detected in surface water and groundwater. Due to its widespread use, an increasing amount of research has focused on the potentially serious environmental and health risks. MATERIAL AND METHO...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yu J,Li X,Yang J,Wu Y,Li B

更新日期：2016-08-11 00:00:00

abstract：:BACKGROUND Leukemia seriously threats human health and life. MicroRNA regulates cell growth, proliferation, apoptosis, and cell cycle. Whether microRNA could be treated as a target for leukemia is still unclear and the mechanism by which microRNA143 regulates K562 cells needs further investigation. MATERIAL AND METHOD...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liang B,Song Y,Zheng W,Ma W

更新日期：2016-08-05 00:00:00

abstract：:BACKGROUND Radiotherapy is explicitly indicated as one of the excluding factors in diagnosing overactive bladder syndrome (OAB). Nevertheless, symptoms of OAB such as urgent episodes, incontinence, pollakiuria, and nocturia, which are consequences of irradiation, led us to test the effectiveness of VESIcare®/Solifenac...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jaszczyński J,Kojs Z,Stelmach A,Wohadło Ł,Łuczyńska E,Heinze S,Rys J,Jakubowicz J,Chłosta P

更新日期：2016-07-30 00:00:00

abstract：:BACKGROUND Nasopharyngeal carcinoma (NPC) is a common malignancy in South-East Asia. NPC is characterized by distant metastasis and poor prognosis. The pathophysiological mechanism of nasopharyngeal carcinoma is unknown. This study aimed to identify the crucial miRNAs in nasopharyngeal carcinoma and their target genes...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu M,Zhu K,Qian X,Li W

更新日期：2016-06-28 00:00:00

abstract：:BACKGROUND MiR-301a and miR-301b are 2 oncomiRs involved in multiple types of cancer. In this study, we explored the expression change of miR-301a and miR-301b in prostate cancer cells in hypoxia and studied their regulation of autophagy and radiosensitivity of prostate cancer cells. MATERIAL AND METHODS QRT-PCR was p...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang W,Liu M,Guan Y,Wu Q

更新日期：2016-06-21 00:00:00

abstract：:BACKGROUND This study was performed with the aim to explore the expression of high-mobility group protein B1 (HMGB1) and the receptor for advanced glycation end-product (RAGE) in knee osteoarthritis (KOA) and its clinical significance. MATERIAL AND METHODS A total of 108 synovial tissues selected from KOA patients wer...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Sun XH,Liu Y,Han Y,Wang J

更新日期：2016-06-20 00:00:00

abstract：:BACKGROUND The prevalence of peripheral arterial disease (PAD) is increasing worldwide. Currently, there is no effective treatment for PAD. Curcumin is an ingredient of turmeric that has antioxidant, anti-inflammation, and anticancer properties. In the present study we investigated the potential effect of curcumin in ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu Y,Chen L,Shen Y,Tan T,Xie N,Luo M,Li Z,Xie X

更新日期：2016-06-15 00:00:00

abstract：:Periodontal diseases are characterized by pathological destruction of extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) are a significant part of the degradation of ECM. However, the regulation of MMPs expression level in periodontal diseases is as yet undetermined. RECK (reversion-in...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu N,Zhou B,Zhu G

更新日期：2016-06-07 00:00:00

abstract：:BACKGROUND We investigated whether the plant-derived agent triptolide (TPL) could effectively inhibit the growth and invasion of human hepatocellular carcinoma (HCC) cells. MATERIAL AND METHODS MHCC-97H cells were treated with various concentration of TPL for various times. To detect the effect of NF-κB on TPL-induced...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang H,Ma D,Wang C,Zhao S,Liu C

更新日期：2016-05-30 00:00:00

abstract：:BACKGROUND Several studies have indicated that interleukin (IL)-1β-511 C/T polymorphism may contribute to individual susceptibility to gastric cancer, but the results vary among regions and races. No relevant meta-analysis has been conducted in a Chinese population. Therefore, we performed the current meta-analysis to...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chen B,Luo MX,Zhou X,Lv Y,Su GQ

更新日期：2016-05-24 00:00:00

abstract：:BACKGROUND Following a thoracolumbar burst fracture (TCBF), anterior screw-rods apply pressure upon the graft site. However, there is limited evidence comparing single screw-rod anterior instrumentation (SSRAI) to double screw-rod anterior instrumentation (DSRAI) for TCBFs. Our objective was to compare SSRAI versus DS...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yu Y,Wang J,Shao G,Wang Q,Li B

更新日期：2016-05-19 00:00:00

abstract：:BACKGROUND Previous studies demonstrated that puerarin has therapeutic effects on cardiac hypertrophy. This study aimed to explore whether the effect of puerarin on attenuating cardiac hypertrophy is related to regulation of microRNAs (miRNAs) and the transforming growth factor beta (TGFβ) signal pathway. MATERIAL AND...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang X,Liu Y,Han Q

更新日期：2016-05-05 00:00:00